Regulation of response to type II interferon

Across TCGA cell cohorts, RNA activity of the Regulation of response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, CYTH3, and IRF9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to type II interferon activity versus TRAP1 in BREAST (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TRAP1 →	+0.747	+0.259	.009	.006	3	8
URINARY_TRACT	CYTH3 →	-1.929	-0.336	<.001	<.001	2	7
BREAST	IRF9 →	-2.696	-0.322	<.001	<.001	3	6
BREAST	DNAJA3 →	+0.672	+0.258	.001	<.001	3	5
LUNG_SCLC	AMOTL2 →	-2.238	-0.204	.001	<.001	3	5
LUNG_SCLC	C16orf91 →	+0.808	+0.216	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060330 vs TRAP1 — BREAST

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