Long-term synaptic depression

Across TCGA patient cohorts, RNA activity of the Long-term synaptic depression pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TYMP, MTA1, and HK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-term synaptic depression activity versus TYMP in HNSC (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TYMP →	+0.558	+0.054	<.001	<.001	3	6
GBM	MTA1 →	-0.461	-0.062	<.001	<.001	3	6
GBM	HK3 →	+0.604	+0.036	.005	.009	3	6
BRCA	NT5DC2 →	-0.494	-0.026	<.001	<.001	3	6
UCEC	SASH3 →	+0.489	+0.050	<.001	<.001	3	5
GBM	SIN3A →	-0.264	-0.052	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060292 vs TYMP — HNSC

Explore this scatter interactively →