Long-term synaptic depression

Across TCGA patient cohorts, RNA activity of the Long-term synaptic depression pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8A1, CRY2, and TMOD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-term synaptic depression activity versus ATP8A1 in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP8A1 →	+1.108	+0.589	<.001	<.001	3	6
LSCC	CRY2 →	+0.372	+0.391	<.001	.001	3	5
GBM	TMOD2 →	+0.798	+0.734	<.001	<.001	3	4
GBM	BSPRY →	+0.353	+0.674	<.001	<.001	3	4
GBM	COL5A1 →	-0.909	-0.432	.002	.002	3	4
LSCC	VWA2 →	+0.814	+0.380	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060292 vs ATP8A1 — GBM

Explore this scatter interactively →