Regulation of feeding behavior

Across TCGA cell cohorts, RNA activity of the Regulation of feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI1, SNX30, and MYL12A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of feeding behavior activity versus GNAI1 in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNAI1 →	+2.752	+0.883	.001	.005	2	6
OVARY	SNX30 →	+0.617	+1.308	.006	.003	3	5
URINARY_TRACT	MYL12A →	+1.209	+0.415	.002	<.001	3	4
LUNG_SCLC	NR2F1 →	+3.300	+0.973	.002	.005	3	4
LUNG_NSCLC_LUAD	BBS12 →	+0.688	+0.765	.003	.002	3	4
KIDNEY	LRP1 →	+1.799	+1.621	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060259 vs GNAI1 — LARGE_INTESTINE

Explore this scatter interactively →