Negative regulation of post-transcriptional gene silencing

Across TCGA cell cohorts, RNA activity of the Negative regulation of post-transcriptional gene silencing pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNG, TMX4, and RRS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of post-transcriptional gene silencing activity versus UNG in LARGE_INTESTINE (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNG →	+0.676	+0.158	.001	<.001	3	5
BREAST	TMX4 →	+1.465	+0.198	.005	.008	2	5
PANCREAS	RRS1 →	+1.051	+0.244	.006	.002	3	4
BLOOD_Lymphoma	TMEM59 →	-0.946	-0.173	.009	.001	3	4
BLOOD_Lymphoma	NUP205 →	+0.723	+0.162	.002	.005	3	4
URINARY_TRACT	KCNRG →	+0.362	+0.277	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060149 vs UNG — LARGE_INTESTINE

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