Inner ear receptor cell development

Across TCGA patient cohorts, RNA activity of the Inner ear receptor cell development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARFGEF3, WDR19, and WDR35, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear receptor cell development activity versus ARFGEF3 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARFGEF3 →	+0.481	+0.030	.003	.001	3	6
BRCA	WDR19 →	+0.369	+0.028	<.001	<.001	3	5
BRCA	WDR35 →	+0.312	+0.024	<.001	<.001	3	5
UCEC	CLIP1 →	-0.182	-0.039	.001	.002	3	5
BRCA	DDAH1 →	+0.539	+0.022	<.001	<.001	3	5
BRCA	IFT122 →	+0.304	+0.029	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060119 vs ARFGEF3 — BRCA

Explore this scatter interactively →