Inner ear receptor cell development

Across TCGA pan-cancer cohorts, RNA activity of the Inner ear receptor cell development pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

HNSC, STAD, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Male	III,IV	+0.028	<.001	11	view →
STAD	All	All	+0.053	<.001	10	view →
LUAD	Female	II,III,IV	+0.043	<.001	8	view →
KIRP	Male	All	+0.033	.001	8	view →
COAD	All	II,III,IV	+0.030	<.001	8	view →
KIRC	Male	All	+0.022	<.001	8	view →
THCA	Male	III,IV	+0.048	.001	6	view →
UCEC	All	III,IV	+0.042	<.001	6	view →
LUSC	Male	II,III,IV	+0.042	<.001	6	view →
BLCA	Female	III,IV	+0.031	.008	6	view →
LIHC	Male	All	+0.022	<.001	5	view →
CHOL	All	All	+0.063	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0060119–HNSC

Open the HNSC breakdown →