Inner ear receptor cell development

Across TCGA patient cohorts, RNA activity of the Inner ear receptor cell development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SP110, SAMD9L, and RPL7AP61, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner ear receptor cell development activity versus SP110 in COAD (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SP110 →	-0.575	-0.918	<.001	<.001	3	4
COAD	SAMD9L →	-0.949	-0.873	<.001	<.001	3	3
PDAC	RPL7AP61 →	-0.089	-0.460	.002	<.001	3	3
UCEC	CYRIA →	-0.464	-0.590	.002	<.001	3	3
UCEC	NAIPP1 →	-0.248	-0.653	.008	.002	3	3
GBM	PACSIN1 →	-1.161	-0.280	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060119 vs SP110 — COAD

Explore this scatter interactively →