Inner ear receptor cell development

Across TCGA cell cohorts, RNA activity of the Inner ear receptor cell development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHCR7, RPF2, and CCNC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHCR7 grouped by Inner ear receptor cell development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DHCR7 →	+1.386	+0.289	<.001	<.001	3	5
KIDNEY	RPF2 →	+0.552	+0.203	.004	.008	2	6
STOMACH	CCNC →	+0.863	+0.295	.003	<.001	3	3
STOMACH	ZBTB2 →	+0.694	+0.280	<.001	<.001	3	3
BLOOD_Myeloma	CEP43 →	+1.180	+0.469	.001	.001	3	3
STOMACH	TMEM242 →	+0.636	+0.307	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHCR7 by Inner ear receptor cell development activity — STOMACH

Explore this box plot interactively →