Micturition

Across TCGA patient cohorts, RNA activity of the Micturition pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC1A4, DOCK11_T1352, and TRAF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Micturition activity versus SLC1A4 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC1A4 →	+0.296	+0.463	<.001	.002	3	5
HNSC	DOCK11_T1352 →	+0.456	+0.572	<.001	.005	3	4
LSCC	TRAF1 →	-0.453	-0.573	<.001	.005	3	4
BRCA	NFKBIE →	-0.319	-0.064	<.001	.005	3	4
LUAD	IDUA →	-0.402	-0.692	.002	<.001	3	4
LSCC	INPP5D_S243 →	-0.568	-0.413	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060073 vs SLC1A4 — LUAD

Explore this scatter interactively →