Micturition

Across TCGA cell cohorts, RNA activity of the Micturition pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC22A, RAP1A, and HNRNPL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC22A grouped by Micturition-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SEC22A →	-0.232	-1.348	.001	.003	3	4
LUNG_SCLC	RAP1A →	-0.270	-1.455	.009	<.001	3	4
OVARY	HNRNPL →	+0.333	+1.370	.002	.003	2	5
OVARY	ABR →	-0.237	-1.307	.008	.005	2	5
CNS	CCN2 →	-0.200	-1.003	<.001	<.001	3	4
BREAST	CYB5R1 →	-0.101	-0.969	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC22A by Micturition activity — KIDNEY

Explore this box plot interactively →