Mammary gland involution

Across TCGA patient cohorts, RNA activity of the Mammary gland involution pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP5, CILP, and MRGPRF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland involution activity versus IGFBP5 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGFBP5 →	+1.486	+0.177	<.001	<.001	3	5
BRCA	CILP →	+0.889	+0.147	.006	<.001	3	4
BRCA	MRGPRF →	+0.742	+0.185	<.001	<.001	3	4
HNSC	CHRDL1 →	+1.217	+0.401	<.001	.005	3	3
HNSC	RNU6-1267P →	+0.631	+0.278	.004	.009	3	3
OV	SERPINE2 →	+1.307	+0.240	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060056 vs IGFBP5 — BRCA

Explore this scatter interactively →