Mammary gland involution

Across TCGA pan-cancer cohorts, RNA activity of the Mammary gland involution pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Mammary gland involution pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

STAD, HNSC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.600	0.875	<.001	44	view →
HNSC	DFS	Median	IV	0.782	0.571	<.001	43	view →
KIRP	OS	Quartile	All	0.555	0.886	.002	37	view →
LGG	OS	Tertile	All	0.364	0.515	.001	33	view →
LAML	DFS	Median	All	0.458	0.663	<.001	30	view →
UCS	DFS	Tertile	IV	0.956	0.380	.024	30	view →
LUSC	DFS	Median	All	0.715	0.797	.003	29	view →
KICH	OS	Median	All	1.000	0.720	.010	19	view →
DLBC	DFS	Median	All	0.858	0.339	.005	19	view →
THCA	DFS	Quartile	II,III,IV	0.589	0.928	.005	18	view →
ESCA	DFS	Median	III,IV	0.446	0.250	.025	15	view →
UVM	DFS	Quartile	II,III,IV	0.496	0.880	.019	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0060056–STAD (DFS)

Open the STAD breakdown →