Angiogenesis involved in wound healing

Across TCGA cell cohorts, RNA activity of the Angiogenesis involved in wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFA, RNMT, and BECN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEGFA grouped by Angiogenesis involved in wound healing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VEGFA →	-0.295	-0.259	.002	<.001	3	6
OVARY	RNMT →	-0.164	-0.708	.005	.006	3	4
KIDNEY	BECN1 →	-0.308	-1.085	.001	.003	3	4
OVARY	PLCD3 →	-0.360	-0.815	<.001	.006	3	4
CNS	ZNF496 →	-0.264	-1.215	.002	<.001	3	4
BONE	KCNH8 →	+0.195	+1.651	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEGFA by Angiogenesis involved in wound healing activity — LUNG_SCLC

Explore this box plot interactively →