Angiogenesis involved in wound healing

Across TCGA pan-cancer cohorts, RNA activity of the Angiogenesis involved in wound healing pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 30 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Angiogenesis involved in wound healing pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRP, UVM, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.563	0.782	<.001	129	view →
UVM	DFS	Median	All	0.373	0.723	<.001	113	view →
DLBC	DFS	Tertile	All	0.406	1.000	.012	42	view →
LUAD	OS	Median	III,IV	0.442	0.221	.009	35	view →
COAD	DFS	Tertile	All	0.717	0.819	.008	34	view →
STAD	OS	Tertile	All	0.441	0.687	.009	30	view →
LGG	DFS	Tertile	All	0.802	0.889	.004	29	view →
SKCM	OS	Tertile	III,IV	0.587	0.269	.002	29	view →
LUSC	OS	Tertile	All	0.268	0.453	.006	17	view →
KIRC	DFS	Median	All	0.564	0.676	.003	16	view →
HNSC	DFS	Quartile	IV	0.748	0.535	.009	15	view →
TGCT	DFS	Tertile	All	0.509	0.792	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0060055–KIRP (OS)

Open the KIRP breakdown →