Positive regulation of epithelial cell proliferation involved in wound healing

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in wound healing pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL39L, VEGFA, and ADM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell proliferation involved in wound healing activity versus RPL39L in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL39L →	+0.729	+0.189	<.001	<.001	3	5
LUAD	VEGFA →	+1.056	+0.223	<.001	<.001	3	4
LUAD	ADM →	+1.098	+0.231	<.001	<.001	3	4
LSCC	CLDN1 →	+1.798	+0.195	<.001	<.001	3	4
LSCC	PELATON →	+0.489	+0.152	.001	<.001	3	4
BRCA	TMIE →	+0.292	+0.356	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060054 vs RPL39L — LUAD

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