Positive regulation of epithelial cell proliferation involved in wound healing

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of epithelial cell proliferation involved in wound healing pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Positive regulation of epithelial cell proliferation involved in wound healing pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and MESO, show the opposite pattern, with higher activity associated with better survival.

LIHC, LAML, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.811	0.575	<.001	60	view →
LAML	DFS	Median	All	0.450	0.681	<.001	42	view →
MESO	OS	Tertile	III,IV	0.694	0.411	.010	31	view →
PAAD	DFS	Median	All	0.165	0.379	<.001	27	view →
KIRP	OS	Quartile	All	0.574	0.893	.007	26	view →
LUAD	DFS	Tertile	IV	0.876	0.139	.011	18	view →
ESCA	OS	Quartile	II,III,IV	0.857	0.563	.005	12	view →
UCEC	OS	Tertile	All	0.647	0.830	.016	10	view →
KIRC	OS	Median	All	0.546	0.694	<.001	10	view →
CHOL	DFS	Median	All	0.129	0.617	.024	9	view →
SCLC	DFS	Median	IV	0.651	0.148	.006	9	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.830	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0060054–LIHC (OS)

Open the LIHC breakdown →