Neurofilament cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Neurofilament cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIAA1671, FERMT2, and FHL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurofilament cytoskeleton organization activity versus KIAA1671 in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIAA1671 →	+0.423	+0.072	<.001	.001	3	7
COAD	FERMT2 →	-0.544	-0.033	<.001	<.001	3	6
COAD	FHL3 →	-0.404	-0.037	.003	.001	3	6
OV	RASA3_S90 →	-0.790	-0.048	.002	.005	3	6
GBM	NEK9 →	-0.196	-0.086	<.001	<.001	3	6
LSCC	RFC4 →	+0.386	+0.070	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060052 vs KIAA1671 — LSCC

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