Neurofilament cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Neurofilament cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELP3, ZNF395, and FBXO21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELP3 grouped by Neurofilament cytoskeleton organization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ELP3 →	-1.205	-0.261	.007	.002	3	5
LUNG_NSCLC_LUAD	ZNF395 →	-0.768	-0.390	.001	.007	3	5
LUNG_SCLC	FBXO21 →	-1.027	-0.232	.002	.004	3	4
SKIN	TTC1 →	-0.542	-0.232	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TNKS →	-0.936	-0.403	.006	.006	3	4
LUNG_SCLC	KCNC1 →	-1.978	-0.268	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELP3 by Neurofilament cytoskeleton organization activity — LIVER

Explore this box plot interactively →