Anatomical structure regression

Across TCGA patient cohorts, RNA activity of the Anatomical structure regression pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, TGFB1I1_S137, and RCN3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anatomical structure regression activity versus CRTAP in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRTAP →	+0.633	+0.080	<.001	<.001	3	9
UCEC	TGFB1I1_S137 →	+0.774	+0.099	<.001	<.001	3	8
GBM	RCN3 →	+0.875	+0.131	<.001	<.001	3	8
GBM	SERPINH1 →	+0.618	+0.133	<.001	<.001	3	8
OV	SFRP2 →	+1.508	+0.093	<.001	<.001	3	8
PDAC	SPON2 →	+0.870	+0.091	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060033 vs CRTAP — BRCA

Explore this scatter interactively →