Anatomical structure regression

Across TCGA pan-cancer cohorts, RNA activity of the Anatomical structure regression pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

HNSC, KIRC, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.073	<.001	12	view →
KIRC	Male	II,III,IV	+0.119	<.001	11	view →
LIHC	Female	II,III,IV	+0.065	<.001	8	view →
KICH	Male	All	+0.083	<.001	7	view →
COAD	All	All	+0.031	.001	7	view →
UCEC	All	II,III,IV	+0.072	.029	6	view →
THCA	All	II,III,IV	+0.061	<.001	6	view →
BRCA	Female	All	+0.023	.003	4	view →
CHOL	All	All	+0.078	.003	2	view →
ESCA	All	All	+0.051	.024	1	view →
LUSC	All	II,III,IV	+0.032	.045	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0060033–HNSC

Open the HNSC breakdown →