Anatomical structure regression

Across TCGA cell cohorts, RNA activity of the Anatomical structure regression pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC6A3, THOC6, and PMPCA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anatomical structure regression activity versus SLC6A3 in LUNG_SCLC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC6A3 →	+0.903	+0.395	<.001	.003	3	3
OESOPHAGUS	THOC6 →	-0.926	-0.504	.008	.001	2	2
SKIN	PMPCA →	+1.196	+0.539	.002	<.001	2	2
BLOOD_Lymphoma	NOC3L →	+0.301	+1.074	.004	.004	3	1
BLOOD_Lymphoma	TH →	+3.081	+1.806	.005	.002	2	2
BLOOD_Lymphoma	OGA →	+0.809	+1.070	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060033 vs SLC6A3 — LUNG_SCLC

Explore this scatter interactively →