Radial glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Radial glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BU1, SEPHS1, and FIBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Radial glial cell differentiation activity versus H2BU1 in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	H2BU1 →	+0.680	+0.369	.006	.001	3	4
LUNG_NSCLC_LUAD	SEPHS1 →	-0.892	-0.372	.004	<.001	3	4
LUNG_SCLC	FIBP →	-0.538	-0.289	<.001	<.001	3	4
BLOOD_Leukemia	STAT3 →	+1.359	+0.445	<.001	<.001	3	4
OESOPHAGUS	ATP5F1B →	-0.848	-0.405	.004	.004	2	4
CNS	ISCU →	-0.622	-0.597	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060019 vs H2BU1 — BLOOD_Leukemia

Explore this scatter interactively →