"Synaptic transmission, glycinergic"

Across TCGA cell cohorts, RNA activity of the "Synaptic transmission, glycinergic" pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAB2, COLQ, and CAMK2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKAB2 grouped by "Synaptic transmission, glycinergic"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRKAB2 →	-0.230	-1.059	<.001	.006	3	4
BLOOD_Leukemia	COLQ →	+0.265	+1.060	.009	.009	3	4
BLOOD_Leukemia	CAMK2A →	+0.186	+1.127	.007	.005	3	4
BONE	RHBG →	-0.537	-1.965	.003	<.001	3	4
BREAST	PDYN →	-0.246	-0.886	.008	.002	2	5
LUNG_NSCLC_LUAD	STX18 →	-0.123	-0.959	.009	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKAB2 by "Synaptic transmission, glycinergic" activity — BLOOD_Leukemia

Explore this box plot interactively →