Reflex

Across TCGA patient cohorts, RNA activity of the Reflex pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRBA, PLEK, and NPNT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reflex activity versus LRBA in BRCA (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRBA →	+0.427	+0.098	<.001	<.001	3	6
CCRCC	PLEK →	-0.368	-0.078	.005	.004	3	6
OV	NPNT →	+1.118	+0.063	.001	<.001	2	7
GBM	FMNL1 →	-0.344	-0.060	.002	.002	3	6
BRCA	ARHGAP32_S682 →	+0.865	+0.080	.009	.005	3	6
GBM	FNBP1 →	-0.230	-0.084	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060004 vs LRBA — BRCA

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