Reflex

Across TCGA patient cohorts, RNA activity of the Reflex pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STMN2, ERMN, and B3GNT6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reflex activity versus STMN2 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STMN2 →	+2.611	+0.717	<.001	.002	3	4
LUAD	ERMN →	+0.442	+0.227	.002	.005	3	4
LUAD	B3GNT6 →	-1.355	-0.147	.003	<.001	3	3
OV	PTGDS →	+1.071	+0.598	.002	<.001	3	3
OV	SEPTIN4 →	+0.631	+0.575	.005	.001	3	3
OV	ENOX1 →	+0.949	+0.556	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060004 vs STMN2 — GBM

Explore this scatter interactively →