Reflex

Across TCGA cell cohorts, RNA activity of the Reflex pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMB, NCOA1, and ZKSCAN2, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reflex activity versus NMB in LUNG_NSCLC_LUSC (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NMB →	+3.098	+2.527	<.001	<.001	3	20
BLOOD_Lymphoma	NCOA1 →	-1.253	-0.776	<.001	.002	3	9
LUNG_SCLC	ZKSCAN2 →	-0.698	-0.833	<.001	.008	2	10
SOFT_TISSUE	ZBTB6 →	-0.672	-1.372	<.001	<.001	3	9
PANCREAS	FAM122A →	-0.644	-1.092	.003	.007	3	8
BLOOD_Leukemia	SUPT7L →	-0.510	-0.874	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060004 vs NMB — LUNG_NSCLC_LUSC

Explore this scatter interactively →