Acylglycerol homeostasis

Across TCGA patient cohorts, RNA activity of the Acylglycerol homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EHD2, TNS1_S1393, and ASPN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acylglycerol homeostasis activity versus EHD2 in BRCA (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EHD2 →	+0.924	+0.061	<.001	<.001	3	6
BRCA	TNS1_S1393 →	+0.927	+0.046	<.001	<.001	3	6
OV	ASPN →	+0.955	+0.045	.001	.001	3	5
CCRCC	SNX4 →	+0.248	+0.066	.001	<.001	3	5
COAD	TRMT2A →	-0.168	-0.033	.001	.001	3	5
COAD	COL8A1 →	+0.604	+0.039	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055090 vs EHD2 — BRCA

Explore this scatter interactively →