Acylglycerol homeostasis

Across TCGA patient cohorts, RNA activity of the Acylglycerol homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4orf3, POMT1, and DIPK1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acylglycerol homeostasis activity versus C4orf3 in COAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C4orf3 →	+0.528	+0.168	<.001	<.001	3	4
BRCA	POMT1 →	+0.326	+0.154	.004	.002	3	4
BRCA	DIPK1B →	+0.513	+0.108	.001	.005	3	4
COAD	TSPAN4 →	+0.741	+0.186	<.001	<.001	3	4
COAD	VIM →	+0.685	+0.166	<.001	<.001	3	4
HNSC	AVPR1A →	+0.529	+0.173	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055090 vs C4orf3 — COAD

Explore this scatter interactively →