Acylglycerol homeostasis

Across TCGA cell cohorts, RNA activity of the Acylglycerol homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIM1, TBC1D2, and CSF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRIM1 grouped by Acylglycerol homeostasis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CRIM1 →	-2.596	-1.587	.007	<.001	3	6
OVARY	TBC1D2 →	-1.523	-0.974	<.001	<.001	3	6
OVARY	CSF1 →	-1.726	-1.095	.006	.001	3	5
SOFT_TISSUE	SH2D5 →	-1.540	-1.269	.001	.001	2	6
LARGE_INTESTINE	FEZ1 →	-0.554	-0.683	.001	.005	3	5
LARGE_INTESTINE	CAVIN1 →	-2.388	-1.040	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRIM1 by Acylglycerol homeostasis activity — STOMACH

Explore this box plot interactively →