Acylglycerol homeostasis

Across TCGA cell cohorts, RNA activity of the Acylglycerol homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICA, PHACTR4, and MTCH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MICA grouped by Acylglycerol homeostasis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MICA →	+0.166	+0.920	.005	.008	3	4
SOFT_TISSUE	PHACTR4 →	-0.196	-2.409	.007	<.001	3	3
LUNG_NSCLC_LUAD	MTCH1 →	+0.135	+0.960	.004	.004	3	3
BREAST	TMC7 →	+0.225	+0.845	.004	.002	3	3
BREAST	WDR87 →	+0.165	+1.094	.001	<.001	3	3
PANCREAS	ALG13 →	+0.209	+1.315	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MICA by Acylglycerol homeostasis activity — PANCREAS

Explore this box plot interactively →