Ventricular cardiac muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECM2, AOC3, and JAM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell differentiation activity versus ECM2 in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ECM2 →	+0.645	+0.687	.006	.002	3	5
CCRCC	AOC3 →	+0.969	+0.616	<.001	.006	3	5
CCRCC	JAM3 →	+0.944	+0.735	<.001	.001	3	5
OV	RAPGEF3 →	+0.866	+0.118	<.001	.001	3	5
UCEC	FGF7 →	+0.746	+0.390	.008	.002	3	5
GBM	PCOLCE →	+0.893	+0.302	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055012 vs ECM2 — CCRCC

Explore this scatter interactively →