Ventricular cardiac muscle cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Ventricular cardiac muscle cell differentiation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Ventricular cardiac muscle cell differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

COAD, MESO, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.729	0.833	.004	45	view →
MESO	OS	Median	II,III,IV	0.298	0.748	.004	44	view →
KICH	OS	Tertile	III,IV	0.475	0.941	.005	42	view →
LIHC	DFS	Median	II,III,IV	0.301	0.514	.001	36	view →
KIRP	DFS	Median	All	0.772	0.908	<.001	35	view →
LUSC	OS	Median	II,III,IV	0.334	0.652	.007	34	view →
SKCM	OS	Tertile	All	0.418	0.257	.001	33	view →
HNSC	OS	Tertile	IV	0.801	0.507	.001	31	view →
UVM	OS	Median	All	0.761	1.000	.008	24	view →
STAD	DFS	Quartile	II,III,IV	0.539	0.691	.018	19	view →
KIRC	DFS	Tertile	All	0.436	0.704	.007	18	view →
LGG	OS	Tertile	All	0.707	0.892	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0055012–COAD (DFS)

Open the COAD breakdown →