Ventricular cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPK, RANBP3, and OGFOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell differentiation activity versus HNRNPK in PANCREAS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HNRNPK →	+0.614	+1.450	.003	.001	3	6
UPPER_AERODIGESTIVE_TRACT	RANBP3 →	+0.888	+1.541	.002	<.001	2	7
UPPER_AERODIGESTIVE_TRACT	OGFOD1 →	+0.935	+1.608	.001	<.001	3	5
BLOOD_Myeloma	SF3A2 →	+0.859	+1.558	.008	<.001	3	5
OVARY	NFIC →	+2.507	+1.333	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	TMPO →	+1.098	+1.404	.001	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055012 vs HNRNPK — PANCREAS

Explore this scatter interactively →