Monoacylglycerol catabolic process

Across TCGA cell cohorts, RNA activity of the Monoacylglycerol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KL1, STX4, and FZD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS6KL1 grouped by Monoacylglycerol catabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPS6KL1 →	+1.234	+1.341	.008	.002	3	4
CNS	STX4 →	-0.936	-1.096	.004	.001	3	4
BLOOD_Leukemia	FZD3 →	+1.090	+1.015	.001	.004	3	3
BLOOD_Leukemia	LSP1 →	-4.875	-1.651	<.001	<.001	3	3
BLOOD_Leukemia	KIAA0040 →	+1.728	+1.066	.001	.002	3	3
BLOOD_Leukemia	NHLRC4 →	+0.864	+1.248	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS6KL1 by Monoacylglycerol catabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →