Regulation of attachment of spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Regulation of attachment of spindle microtubules to kinetochore pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RRM2, and SMC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of attachment of spindle microtubules to kinetochore activity versus RFC2 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.447	+0.083	<.001	<.001	3	9
LUAD	RRM2 →	+1.022	+0.160	<.001	<.001	3	9
GBM	SMC2 →	+0.795	+0.157	<.001	<.001	3	9
GBM	SMC4 →	+0.770	+0.152	<.001	<.001	3	9
LUAD	TOP2A_S1106 →	+1.454	+0.153	<.001	<.001	3	9
LUAD	TOP2A_S1247 →	+1.644	+0.154	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051988 vs RFC2 — LSCC

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