Positive regulation of chromosome segregation

Across TCGA patient cohorts, RNA activity of the Positive regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, CEP55, and NUF2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromosome segregation activity versus LMNB1 in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LMNB1 →	+0.930	+0.576	<.001	.003	3	9
BRCA	CEP55 →	+1.403	+1.030	<.001	<.001	3	9
BRCA	NUF2 →	+1.542	+1.139	<.001	<.001	3	9
LSCC	CENPH →	+0.720	+0.270	<.001	<.001	3	9
BRCA	E2F2 →	+1.028	+0.997	<.001	<.001	3	9
BRCA	KIF14 →	+1.200	+1.015	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051984 vs LMNB1 — GBM

Explore this scatter interactively →