Positive regulation of chromosome segregation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of chromosome segregation pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 27 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Positive regulation of chromosome segregation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRP, MESO, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.565	0.785	<.001	144	view →
MESO	OS	Median	II,III,IV	0.258	0.534	<.001	135	view →
ACC	OS	Median	All	0.371	0.799	<.001	130	view →
KIRC	DFS	Median	All	0.493	0.722	<.001	126	view →
HNSC	DFS	Tertile	All	0.774	0.633	.002	115	view →
KICH	DFS	Median	All	0.719	0.977	<.001	111	view →
LIHC	DFS	Median	All	0.454	0.622	<.001	86	view →
UVM	DFS	Quartile	III,IV	0.141	0.764	<.001	80	view →
THCA	DFS	Median	All	0.839	0.936	<.001	71	view →
UCS	OS	Quartile	III,IV	0.588	0.273	.019	58	view →
LGG	OS	Median	All	0.699	0.909	<.001	54	view →
LUAD	OS	Tertile	All	0.249	0.441	<.001	45	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0051984–KIRP (OS)

Open the KIRP breakdown →