Medium-chain fatty acid catabolic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD3, TMED5, and STXBP3, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty acid catabolic process activity versus ABHD3 in DLBC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ABHD3 →	+1.651	+0.125	<.001	<.001	3	33
KICH	TMED5 →	+1.528	+0.098	<.001	<.001	3	27
DLBC	STXBP3 →	+1.332	+0.121	<.001	<.001	3	27
DLBC	ROCK1 →	+2.015	+0.117	<.001	<.001	3	27
UVM	ACADM →	+1.980	+0.105	<.001	<.001	3	26
DLBC	HEATR5A →	+1.197	+0.132	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051793 vs ABHD3 — DLBC

Explore this scatter interactively →