Medium-chain fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDAH2, MYL6B, and EEF2_T435, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty acid biosynthetic process activity versus DDAH2 in OV (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDAH2 →	-0.503	-0.099	<.001	<.001	3	7
CCRCC	MYL6B →	-0.473	-0.067	<.001	<.001	3	7
LSCC	EEF2_T435 →	+0.639	+0.057	<.001	<.001	3	6
UCEC	ACOT7 →	+0.479	+0.117	<.001	<.001	3	6
PDAC	SMC4 →	+0.296	+0.058	.001	<.001	3	6
PDAC	POLD3 →	+0.254	+0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051792 vs DDAH2 — OV

Explore this scatter interactively →