Negative regulation of nuclear division

Across TCGA patient cohorts, RNA activity of the Negative regulation of nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIAPH3, SKA3, and PLK1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nuclear division activity versus DIAPH3 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DIAPH3 →	+1.067	+0.961	.001	<.001	3	9
BRCA	SKA3 →	+1.152	+0.884	<.001	<.001	3	9
BRCA	PLK1 →	+1.177	+0.866	<.001	<.001	3	9
BRCA	HASPIN →	+0.961	+1.009	<.001	<.001	3	9
LUAD	IQGAP3 →	+1.438	+0.471	<.001	<.001	3	9
BRCA	ASPM →	+1.385	+0.950	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051784 vs DIAPH3 — OV

Explore this scatter interactively →