Negative regulation of nuclear division

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of nuclear division pathway is associated with patient survival in 31 of 34 cancer lineages. Pathway activity is summarized from the expression of its 63 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Negative regulation of nuclear division pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and GBM, show the opposite pattern, with higher activity associated with better survival.

ACC, MESO, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.368	0.824	<.001	148	view →
MESO	OS	Median	All	0.351	0.732	<.001	138	view →
KIRP	DFS	Median	All	0.751	0.935	<.001	131	view →
KIRC	DFS	Median	All	0.529	0.715	<.001	128	view →
KICH	DFS	Quartile	All	0.462	1.000	<.001	105	view →
LIHC	DFS	Median	All	0.442	0.633	<.001	102	view →
UVM	DFS	Quartile	III,IV	0.196	0.832	.001	76	view →
LUAD	OS	Median	All	0.230	0.442	<.001	75	view →
THCA	DFS	Median	All	0.743	0.878	<.001	67	view →
HNSC	OS	Tertile	IV	0.546	0.309	.002	58	view →
LGG	OS	Median	All	0.710	0.911	<.001	54	view →
SARC	DFS	Tertile	All	0.537	0.720	<.001	34	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

GO:0051784–ACC (OS)

Open the ACC breakdown →