Negative regulation of nuclear division

Across TCGA cell cohorts, RNA activity of the Negative regulation of nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP10, ZCWPW2, and SOWAHB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP10 grouped by Negative regulation of nuclear division-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DUSP10 →	+2.105	+0.194	.005	.008	3	5
LIVER	ZCWPW2 →	-0.236	-0.360	.003	.002	3	5
OVARY	SOWAHB →	+0.969	+0.197	.002	<.001	3	5
CNS	COPS9 →	-0.486	-0.131	<.001	.006	3	4
LUNG_NSCLC_LUSC	EEF1A2 →	+3.468	+0.224	<.001	.002	3	4
PANCREAS	RAB38 →	+1.920	+0.203	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP10 by Negative regulation of nuclear division activity — LUNG_SCLC

Explore this box plot interactively →