Biological process involved in interaction with symbiont

Across TCGA patient cohorts, RNA activity of the Biological process involved in interaction with symbiont pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TROAP, SNORD14E, and HELLS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biological process involved in interaction with symbiont activity versus TROAP in LUAD (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TROAP →	+0.683	+0.155	<.001	<.001	3	6
LUAD	SNORD14E →	+0.885	+0.171	.001	<.001	3	6
LUAD	HELLS →	+0.754	+0.168	<.001	.005	3	5
OV	RFC4 →	+0.565	+0.145	.007	.009	3	5
LUAD	SPAG5 →	+0.770	+0.180	<.001	<.001	3	5
PDAC	C7 →	-1.038	-0.168	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051702 vs TROAP — LUAD

Explore this scatter interactively →