Membrane raft localization

Across TCGA patient cohorts, RNA activity of the Membrane raft localization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, SEPTIN1, and SEPTIN6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane raft localization activity versus SASH3 in UCEC (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SASH3 →	+0.571	+0.132	<.001	<.001	3	10
LSCC	SEPTIN1 →	+0.936	+0.198	<.001	<.001	3	10
LSCC	SEPTIN6 →	+0.592	+0.209	<.001	<.001	3	10
HNSC	STAT5A →	+0.495	+0.191	<.001	<.001	3	10
GBM	WAS →	+0.640	+0.165	<.001	<.001	3	10
LSCC	WDFY4 →	+0.649	+0.210	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051665 vs SASH3 — UCEC

Explore this scatter interactively →