Membrane raft localization

Across TCGA pan-cancer cohorts, RNA activity of the Membrane raft localization pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Membrane raft localization pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

UCEC, HNSC, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.493	0.767	<.001	70	view →
HNSC	OS	Quartile	All	0.813	0.674	.001	62	view →
LUAD	DFS	Median	All	0.735	0.598	<.001	48	view →
ESCA	OS	Tertile	III,IV	0.824	0.464	.002	40	view →
KIRP	OS	Tertile	III,IV	0.139	0.678	.010	31	view →
CESC	DFS	Quartile	All	0.923	0.760	.006	30	view →
BRCA	DFS	Median	IV	0.952	0.517	.003	27	view →
MESO	OS	Tertile	All	0.239	0.404	.023	25	view →
THCA	DFS	Tertile	All	0.676	0.918	.003	25	view →
COAD	OS	Tertile	II,III,IV	0.732	0.894	.015	17	view →
UVM	OS	Quartile	All	0.809	0.459	.015	16	view →
DLBC	OS	Median	III,IV	1.000	0.623	.013	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0051665–UCEC (OS)

Open the UCEC breakdown →