Maintenance of centrosome location

Across TCGA cell cohorts, RNA activity of the Maintenance of centrosome location pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAD2L2, ZFP36, and MBD4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAD2L2 grouped by Maintenance of centrosome location-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAD2L2 →	-0.908	-0.252	.008	.001	3	2
STOMACH	ZFP36 →	+1.748	+0.425	.003	.001	3	2
STOMACH	MBD4 →	+0.466	+0.365	.005	.005	3	2
STOMACH	CNKSR1 →	+2.465	+0.392	.005	<.001	3	2
BLOOD_Lymphoma	GSE1 →	+3.208	+1.994	.002	<.001	3	2
BLOOD_Lymphoma	ANO9 →	+1.812	+1.994	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAD2L2 by Maintenance of centrosome location activity — STOMACH

Explore this box plot interactively →