Maintenance of centrosome location

Across TCGA pan-cancer cohorts, RNA activity of the Maintenance of centrosome location pathway is associated with patient survival in 31 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Maintenance of centrosome location pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and THCA, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.407	0.793	<.001	151	view →
KIRC	DFS	Median	All	0.544	0.687	<.001	151	view →
MESO	OS	Tertile	All	0.357	0.619	<.001	96	view →
UCEC	DFS	Tertile	All	0.519	0.751	<.001	80	view →
UCS	DFS	Quartile	II,III,IV	0.572	0.123	.012	54	view →
PAAD	OS	Median	All	0.513	0.688	.002	46	view →
BLCA	DFS	Tertile	All	0.426	0.691	.001	43	view →
LUAD	OS	Tertile	All	0.284	0.473	<.001	43	view →
KIRP	OS	Quartile	All	0.815	0.942	.002	39	view →
CESC	DFS	Median	III,IV	0.204	0.684	.001	32	view →
THCA	DFS	Tertile	All	0.904	0.758	<.001	32	view →
HNSC	DFS	Tertile	IV	0.751	0.569	.007	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

GO:0051661–ACC (OS)

Open the ACC breakdown →