Nucleus localization

Across TCGA cell cohorts, RNA activity of the Nucleus localization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7, TERF2IP, and SF3A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP7 grouped by Nucleus localization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAP7 →	+2.236	+0.218	.003	.005	3	4
STOMACH	TERF2IP →	-0.651	-0.215	.003	.006	3	4
LARGE_INTESTINE	SF3A3 →	-0.389	-0.140	.004	.001	2	4
LARGE_INTESTINE	XRCC1 →	-0.637	-0.161	.004	.002	3	3
URINARY_TRACT	MZT2A →	+1.689	+0.573	.009	.002	3	3
BONE	SFRP1 →	+2.384	+0.353	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP7 by Nucleus localization activity — STOMACH

Explore this box plot interactively →