Mitochondrion localization

Across TCGA cell cohorts, RNA activity of the Mitochondrion localization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM13A, ZCRB1, and NBPF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM13A grouped by Mitochondrion localization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM13A →	-0.841	-0.260	.003	.007	2	6
LUNG_NSCLC_LUAD	ZCRB1 →	+0.731	+0.171	<.001	.001	3	4
LUNG_NSCLC_LUAD	NBPF1 →	+0.640	+0.180	.004	.003	3	4
BLOOD_Myeloma	SNTA1 →	-0.996	-0.323	.002	.001	2	4
BREAST	BUD13 →	-0.717	-0.155	.003	.004	3	3
BLOOD_Myeloma	PCP2 →	+0.594	+0.390	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM13A by Mitochondrion localization activity — OESOPHAGUS

Explore this box plot interactively →